Correlation among Hemolysis Biomarkers in Pediatric Patients Undergoing Extracorporeal Membrane Oxygenation

Hemolysis is a common complication associated with mortality on extracorporeal membrane oxygenation (ECMO). Plasma-free hemoglobin (PFH) the most commonly used biomarker reported for hemolysis ECMO. This test not readily available at all institutions, and other more tests may indicate nearly as well or PFH. The purpose of this study was to correlation biomarkers PFH All patients younger than 21 years placed ECMO in quaternary children's hospital between January 2013 December 2016 were included study; (urine [U-Hb], PFH, lactate dehydrogenase [LDH], aspartate aminotransferase [AST], gross hemolysis, red cell distribution width (RDW)) collected from medical record. Descriptive statistics repeated bivariate analyses determined using SPSS 22.0. median age day 0 29 days (.08 years) (IQR: 2; 319 (.005; .875 years)). weight 3.9 kg 2.8; 8.6), total duration run 10.48 4.25; 14), 82% being venoarterial There no hematuria urinalysis level ( p = .338). statistically significant positive following respective biomarkers: routine chemistry studies < .01, Rho .439), AST RDW .190), LDH .584), (when elevated alanine transaminase (ALT) levels censored) .552). U-Hb correlated poorly serum (in absence ALT elevation) can be useful surrogates quantify pediatric patients.